Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 15/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2584137 | 0.80 | OPRK1 (0.42) | OPRK1NR4A2 | |
| SCHEMBL701198 | 0.76 | NR4A2 (0.38) | OPRK1NR4A2MAPK1 | |
| SCHEMBL2581893 | 0.76 | NR4A2 (0.38) | OPRK1NR4A2LMNASMN1; SMN2MAPK1 | |
| SCHEMBL27832044 | 0.74 | NR4A2 (0.36) | OPRK1NR4A2MAPK1 | |
| SCHEMBL16225311 | 0.72 | PARP1 (0.48) | OPRK1 | |
| SCHEMBL719368 | 0.70 | PDK2 (0.39) | NR4A2LMNAPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL20135394 | 0.69 | KDM4E (0.48) | TDO2 | |
| SCHEMBL10325525 | 0.68 | MEN1 (0.50) | — | |
| SCHEMBL17439541 | 0.68 | MAP2K4 (0.50) | LMNA | |
| SCHEMBL28501362 | 0.68 | KDM4E (0.46) | NR4A2LMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |