Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592544 | 0.85 | PPARA (0.40) | DYRK1AHSD17B10 | |
| SCHEMBL2592617 | 0.84 | MAP2K4 (0.41) | MAPK1KDM4ESTAT3HIF1ATSHR | |
| SCHEMBL2593108 | 0.84 | NQO2 (0.40) | MAPK1KDM4ESTAT3HIF1ATSHR | |
| SCHEMBL701198 | 0.78 | NR4A2 (0.38) | NR4A2CHEK1MAPK1KDM4ESTAT3 | |
| SCHEMBL2589397 | 0.76 | OPRK1 (0.38) | NR4A2MAPK1LMNASMN1; SMN2OPRK1 | |
| SCHEMBL27832044 | 0.76 | NR4A2 (0.36) | NR4A2CHEK1MAPK1KDM4ESTAT3 | |
| SCHEMBL2581802 | 0.74 | MAP2K4 (0.37) | LMNAMAPTALDH1A1 | |
| SCHEMBL2591509 | 0.74 | ALDH1A1 (0.44) | KDM4ETSHRLMNASMN1; SMN2MAPT | |
| SCHEMBL25009349 | 0.71 | OPRK1 (0.47) | MAPK1KDM4ELMNASMN1; SMN2OPRK1 | |
| SCHEMBL28501362 | 0.69 | KDM4E (0.46) | NR4A2MAPK1KDM4ESTAT3HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |