Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25894262 | 0.83 | POLB (0.44) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL25893944 | 0.77 | ALDH1A1 (0.58) | KMT2ASMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL19134244 | 0.74 | NPSR1 (0.50) | RAB9AKMT2ALMNAMEN1 | |
| SCHEMBL20246743 | 0.73 | SMN1; SMN2 (0.48) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10085163 | 0.72 | NPSR1 (0.53) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10078381 | 0.72 | NPSR1 (0.53) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL31532555 | 0.72 | NPSR1 (0.53) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21340181 | 0.72 | NPSR1 (0.53) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL18613033 | 0.72 | NPSR1 (0.53) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14110289 | 0.72 | NPSR1 (0.53) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968347-B1 | MODULATORS OF THE EIF2ALPHA PATHWAY | UNIV CALIFORNIA (US) | 2023-08-02 | — | — | EP | disclosed |