Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589762 | 0.82 | HCRTR2 (0.57) | HCRTR2HCRTR1HTTL3MBTL1ALDH1A1 | |
| SCHEMBL7710724 | 0.80 | HCRTR2 (0.70) | HCRTR2HCRTR1HTTL3MBTL1ALDH1A1 | |
| SCHEMBL2589693 | 0.79 | HCRTR2 (0.47) | HCRTR2HCRTR1HTTATML3MBTL1 | |
| SCHEMBL2591733 | 0.79 | HCRTR2 (0.55) | HCRTR2HCRTR1HTTL3MBTL1ALDH1A1 | |
| SCHEMBL2585096 | 0.75 | HCRTR2 (0.74) | HCRTR2HCRTR1HTTL3MBTL1ALDH1A1 | |
| SCHEMBL2586420 | 0.74 | HCRTR2 (0.54) | HCRTR2HCRTR1HTTL3MBTL1ALDH1A1 | |
| SCHEMBL7707423 | 0.72 | HCRTR2 (1.00) | HCRTR2HCRTR1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2594270 | 0.69 | HCRTR2 (0.75) | HCRTR2HCRTR1L3MBTL1ALDH1A1HPGD | |
| SCHEMBL7706361 | 0.68 | HCRTR2 (0.62) | HCRTR2HCRTR1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7710901 | 0.68 | HCRTR2 (1.00) | HCRTR2HCRTR1L3MBTL1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |