Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 7/20 | 1.00 |
| ▸ | HCRTR1 | O43613 | 6/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710901 | 0.94 | HCRTR2 (1.00) | HCRTR2HCRTR1NPC1RAB9ATSPO | |
| SCHEMBL7709453 | 0.92 | HCRTR2 (1.00) | HCRTR2HCRTR1NPC1RAB9ATSPO | |
| SCHEMBL7707649 | 0.91 | HCRTR2 (0.82) | HCRTR2HCRTR1TSPOALDH1A1POLB | |
| SCHEMBL7701854 | 0.87 | HCRTR2 (0.86) | HCRTR2HCRTR1NPC1RAB9ATSPO | |
| SCHEMBL2585096 | 0.85 | HCRTR2 (0.74) | HCRTR2HCRTR1KMT2AALDH1A1POLB | |
| SCHEMBL7709056 | 0.85 | HCRTR2 (0.82) | HCRTR2HCRTR1TSPOKMT2AALDH1A1 | |
| SCHEMBL7707551 | 0.83 | HCRTR2 (0.71) | HCRTR2HCRTR1TSPOKMT2AALDH1A1 | |
| SCHEMBL7710724 | 0.83 | HCRTR2 (0.70) | HCRTR2HCRTR1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2594270 | 0.78 | HCRTR2 (0.75) | HCRTR2HCRTR1NPC1RAB9AKMT2A | |
| SCHEMBL2584748 | 0.76 | HCRTR2 (0.63) | HCRTR2HCRTR1TSPOKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |