Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648916 | 0.93 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL30131336 | 0.93 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL30644588 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL29229156 | 0.75 | KDM4E (0.45) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP3A4 | |
| Formic Acid SCHEMBL28210582 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3412671 | 0.75 | ALDH1A1 (0.46) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL29535774 | 0.75 | KDM4E (0.61) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL209954 | 0.75 | KDM4E (0.61) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL2393997 | 0.74 | TRIM24 (0.50) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL365395 | 0.73 | ALDH1A1 (0.45) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138293-A1 | 2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-10 | — | — | WO | disclosed |