Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588592 | 0.81 | SNCA (0.41) | LTB4R2MEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL3754160 | 0.79 | KCNA5 (0.41) | LTB4R2RIPK1LMNAALDH1A1MAPT | |
| SCHEMBL2454761 | 0.77 | MEN1 (0.42) | SLC6A2SLC6A4MEN1KMT2AHTT | |
| SCHEMBL2577295 | 0.76 | RAB9A (0.39) | MEN1KMT2AHTTL3MBTL1KEAP1 | |
| SCHEMBL14718502 | 0.74 | KEAP1 (0.42) | LTB4R2HDAC3HDAC1HDAC2KMT2A | |
| SCHEMBL335254 | 0.74 | MEN1 (0.50) | MEN1KMT2AHTTL3MBTL1RIPK1 | |
| SCHEMBL14718500 | 0.73 | HTT (0.43) | HDAC3HDAC1HDAC2KMT2AHTT | |
| SCHEMBL356816 | 0.72 | MEN1 (0.51) | MEN1KMT2AHTTL3MBTL1RIPK1 | |
| SCHEMBL1726029 | 0.72 | MEN1 (0.40) | HDAC3HDAC1MEN1KMT2AHTT | |
| SCHEMBL14726490 | 0.72 | GRM2 (0.57) | HDAC3HDAC1HDAC2L3MBTL1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137219-A1 | INHIBITORS OF PHOSPHOINOSITIDE DEPENDENT KINASE 1 (PDK1) | SCHERING CORPORATION (US) | 2011-11-03 | — | — | WO | disclosed |