Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 0.47 |
| ▸ | NOS3 | P29474 | 8/20 | 0.47 |
| ▸ | NOS1 | P29475 | 5/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17068258 | 0.84 | TBK1 (0.46) | NOS2NOS3NOS1PLAUTBK1 | |
| SCHEMBL18266945 | 0.79 | CYP2A6 (0.42) | NOS2NOS3PLAUCCR1CCR5 | |
| SCHEMBL25323204 | 0.76 | NOS3 (0.39) | NOS2NOS3NOS1PLAUF12 | |
| SCHEMBL30551090 | 0.76 | AXL (0.48) | NOS2NOS3NOS1PLAUF12 | |
| SCHEMBL25323059 | 0.76 | AXL (0.48) | NOS2NOS3NOS1PLAUF12 | |
| SCHEMBL30551124 | 0.76 | NOS3 (0.39) | NOS2NOS3NOS1PLAUF12 | |
| SCHEMBL24493088 | 0.76 | NOS3 (0.36) | NOS2NOS3NOS1PLAUF12 | |
| SCHEMBL16006827 | 0.73 | CYP1A2 (0.54) | NOS2NOS3NOS1PLAUF12 | |
| SCHEMBL24493090 | 0.70 | NOS2 (0.48) | NOS2NOS3NOS1PLAUF12 | |
| SCHEMBL18266944 | 0.69 | CCR1 (0.32) | CCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |