Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25308580 | 0.90 | GPR119 (0.42) | GPR119USP30MEN1KMT2AMMP13 | |
| SCHEMBL25309999 | 0.89 | GPR119 (0.41) | GPR119USP30HDAC4ALDH1A1NPC1 | |
| SCHEMBL25308693 | 0.89 | GPR119 (0.41) | GPR119USP30HDAC4ALDH1A1NPC1 | |
| SCHEMBL28983592 | 0.86 | KDM4E (0.41) | GPR119USP30HDAC4ALDH1A1NPC1 | |
| SCHEMBL24461317 | 0.82 | TRPV3 (0.45) | GPR119USP30HDAC4ALDH1A1NPC1 | |
| SCHEMBL25899721 | 0.80 | GPR119 (0.46) | GPR119USP30ALDH1A1NPC1MAPT | |
| SCHEMBL25309101 | 0.80 | GPR119 (0.51) | GPR119ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL21673835 | 0.78 | GPR119 (0.42) | GPR119ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL24756985 | 0.78 | KDM4E (0.42) | GPR119ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL21405219 | 0.78 | MAP4K4 (0.42) | GPR119USP30ALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141570-A9 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2023141570-A2 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |