Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.53 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.47 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591221 | 0.89 | HSD11B1 (0.48) | HSD11B1TRPC6SMN1; SMN2CCR1ACHE | |
| SCHEMBL2593449 | 0.87 | TRPC6 (0.50) | HSD11B1TRPC3TRPC6FASNLMNA | |
| SCHEMBL2593742 | 0.87 | HSD11B1 (0.58) | HSD11B1TRPC3TRPC6SMN1; SMN2ACHE | |
| SCHEMBL12183553 | 0.87 | HSD11B1 (0.55) | HSD11B1TRPC3TRPC6SMN1; SMN2KMT2A | |
| SCHEMBL2591255 | 0.81 | HSD11B1 (0.56) | HSD11B1TRPC3TRPC6SMN1; SMN2ACHE | |
| SCHEMBL12753327 | 0.77 | HSD11B1 (0.69) | HSD11B1TRPC3TRPC6SMN1; SMN2GRM5 | |
| SCHEMBL15188020 | 0.76 | HSD11B1 (0.50) | HSD11B1TRPC3TRPC6SMN1; SMN2ACHE | |
| SCHEMBL12751750 | 0.76 | HSD11B1 (0.67) | HSD11B1TRPC3TRPC6SMN1; SMN2ACHE | |
| SCHEMBL27914108 | 0.76 | PRKCQ (0.53) | HSD11B1KMT2AMAPT | |
| SCHEMBL2593371 | 0.76 | HSD11B1 (0.47) | HSD11B1SMN1; SMN2GRM5KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130210811-A1 | PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME | SK CHEMICALS CO., LTD. (KR) | 2013-08-15 | — | — | US | claimed |
| EP-2566859-A2 | PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Sk Chemicals Co., Ltd. (KR) | 2013-03-13 | — | — | EP | claimed |
| WO-2011139107-A2 | PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME | SK CHEMICALS CO.,LTD. (KR) | 2011-11-10 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210811-A1 | PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME | HSD11B1, HSD11B2, G6PC1 | HSD11B1 1/4885TRPC3 4165/4885TRPC6 4676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.