Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26029082 | 0.86 | TDP1 (0.43) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL16996966 | 0.85 | TDP1 (0.48) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL25903398 | 0.84 | MAPK1 (0.32) | TDP1MAPK1EPHX2 | |
| SCHEMBL26022242 | 0.84 | TDP1 (0.42) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL25313638 | 0.81 | APLNR (0.33) | SMN1; SMN2 | |
| SCHEMBL25903400 | 0.81 | LTA4H (0.42) | KMT2ASMN1; SMN2MAPTCYP19A1HSD17B10 | |
| SCHEMBL25903505 | 0.79 | TDP1 (0.43) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL25903640 | 0.79 | CHRNB2 (0.46) | MAPT | |
| SCHEMBL16997128 | 0.79 | TDP1 (0.50) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL26022239 | 0.78 | TDP1 (0.46) | TDP1MAPK1EPHX2HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |