Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | SI | P14410 | 3/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.40 |
| ▸ | TUBB | P07437 | 2/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593168 | 0.80 | CYP3A4 (0.51) | CYP3A4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2593326 | 0.74 | ADORA1 (0.39) | ADORA1MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL18904673 | 0.73 | ERN1 (0.56) | ERN1PIK3CD | |
| SCHEMBL2743641 | 0.70 | ATM (0.49) | CYP3A4KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL2581714 | 0.69 | LMNA (0.55) | CYP3A4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL18909533 | 0.67 | ERN1 (0.55) | KDM4EALDH1A1HPGDERN1 | |
| SCHEMBL28085897 | 0.66 | ESR2 (0.47) | ALDH1A1HPGDHSD17B10PIK3CAESR2 | |
| SCHEMBL2589152 | 0.66 | PRF1 (0.47) | CYP3A4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2585417 | 0.66 | HSD17B1 (0.52) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL7710978 | 0.66 | PRKCG (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |