Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22888386 | 0.88 | IKBKB (0.46) | MAPTMAPK1TDP1L3MBTL1IKBKB | |
| SCHEMBL17833744 | 0.81 | CHRNA7 (0.47) | MAPTMAPK1TDP1L3MBTL1GLRA1 | |
| SCHEMBL12556342 | 0.79 | LIPE (0.55) | MAPTMAPK1TDP1L3MBTL1GLRA1 | |
| SCHEMBL4566984 | 0.78 | MCL1 (0.54) | MAPTTDP1L3MBTL1GLRA1PTGER1 | |
| SCHEMBL4566994 | 0.78 | GLRA1 (0.44) | MAPTMAPK1TDP1L3MBTL1GLRA1 | |
| SCHEMBL12659923 | 0.77 | L3MBTL1 (0.53) | MAPTTDP1L3MBTL1GLRA1BRD4 | |
| SCHEMBL25146420 | 0.76 | MAPK1 (0.53) | MAPTMAPK1TDP1L3MBTL1GLRA1 | |
| SCHEMBL19078684 | 0.76 | RXRA (0.49) | MAPTMAPK1TDP1L3MBTL1GLRA1 | |
| SCHEMBL15218612 | 0.75 | MAPT (0.46) | MAPTMAPK1TDP1L3MBTL1GLRA1 | |
| SCHEMBL13114653 | 0.75 | MAPT (0.53) | MAPTMAPK1TDP1L3MBTL1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | AAAS, PROC, AADAC | MAPT 4494/4885MAPK1 4577/4885TDP1 2795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.