Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.39 |
| ▸ | TRAP1 | Q12931 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28346620 | 0.89 | TAAR1 (0.44) | TAAR1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30360689 | 0.80 | CYP3A4 (0.48) | TAAR1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL17980277 | 0.80 | CYP3A4 (0.48) | TAAR1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1520657 | 0.77 | CYP3A4 (0.44) | TAAR1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28904709 | 0.76 | TAAR1 (0.52) | TAAR1CYP3A4MEN1KMT2AHSP90AA1 | |
| SCHEMBL6239134 | 0.76 | CYP1A2 (0.44) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL6239124 | 0.76 | CYP3A4 (0.41) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL6987564 | 0.76 | CYP3A4 (0.41) | TAAR1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11182069 | 0.75 | CYP3A4 (0.43) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL281746 | 0.75 | CYP3A4 (0.46) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708377-B2 | Analogues and derivatives of cephalotaxine and methods for making and using the compounds | OREGON STATE UNIVERSITY (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708377-B2 | Analogues and derivatives of cephalotaxine and methods for making and using the compounds | OREGON STATE UNIVERSITY (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708377-B2 | Analogues and derivatives of cephalotaxine and methods for making and using the compounds | SLC6A2, NAPRT, SLC6A3 | TAAR1 882/4885CYP3A4 2094/4885CYP1A2 255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.