Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 5/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987564 | 0.82 | CYP3A4 (0.41) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL17980277 | 0.76 | CYP3A4 (0.48) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL30360689 | 0.76 | CYP3A4 (0.48) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL6239134 | 0.75 | CYP1A2 (0.44) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL8433655 | 0.75 | CYP1A2 (0.43) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL28346620 | 0.73 | TAAR1 (0.44) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL1520657 | 0.72 | CYP3A4 (0.44) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL11053658 | 0.71 | TAAR1 (0.61) | CYP3A4CYP1A2CYP2C19ALDH1A1MAPT | |
| SCHEMBL11182069 | 0.71 | CYP3A4 (0.43) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL281746 | 0.71 | CYP3A4 (0.46) | CYP3A4CYP1A2CYP2D6CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256159-A1 | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
| EP-1556349-A1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS 11-BETAHSD1 INHIBITORS | Astrazeneca AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004033427-A1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS 11-BETAHSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256159-A1 | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors | HSD11B1, HSD3B1, P4HA1 | CYP3A4 241/4885CYP1A2 53/4885CYP2D6 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.