Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.43 |
| ▸ | HTR2A | P28223 | 11/20 | 0.43 |
| ▸ | HTR7 | P34969 | 11/20 | 0.43 |
| ▸ | HTR6 | P50406 | 11/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25318723 | 0.89 | HTR1A (0.46) | HTR1AHTR2AHTR7HTR6MMP1 | |
| SCHEMBL25317717 | 0.84 | HTR1A (0.48) | HTR1AHTR2AHTR7HTR6MMP1 | |
| SCHEMBL25315766 | 0.81 | HRH3 (0.48) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25315078 | 0.76 | HTR1A (0.42) | HTR1AHTR2AHTR7HTR6HRH3 | |
| SCHEMBL30507061 | 0.76 | HTR1A (0.42) | HTR1AHTR2AHTR7HTR6HRH3 | |
| SCHEMBL25908381 | 0.76 | HTR1A (0.41) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25317666 | 0.75 | ALK (0.42) | HTR2AHRH3KCNH2CA12CA1 | |
| SCHEMBL25316295 | 0.75 | HTR1A (0.47) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL4772435 | 0.73 | HTR1A (0.54) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25928826 | 0.73 | MEN1 (0.41) | HTR1AHTR2AHTR7HTR6MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |