Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.54 |
| ▸ | HTR2A | P28223 | 12/20 | 0.54 |
| ▸ | HTR7 | P34969 | 12/20 | 0.54 |
| ▸ | HTR6 | P50406 | 12/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.52 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302359 | 0.80 | HTR7 (0.62) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL31623081 | 0.78 | OPRM1 (0.53) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL8328393 | 0.78 | OPRM1 (0.53) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25317024 | 0.78 | HTR7 (0.62) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL2298743 | 0.77 | OPRM1 (0.63) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL1700315 | 0.77 | OPRM1 (0.58) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL7978260 | 0.75 | OPRK1 (0.49) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25317717 | 0.75 | HTR1A (0.48) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25362520 | 0.74 | OPRM1 (0.56) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25362517 | 0.74 | OPRM1 (0.56) | HTR1AHTR2AHTR7HTR6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890696-A2 | NOVEL 3-SPIROCYCLIC INDOLYL DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006130416-A2 | NOVEL 3-SPIROCYCLIC INDOLYL DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | disclosed |