Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.41 |
| ▸ | HTR2A | P28223 | 12/20 | 0.41 |
| ▸ | HTR7 | P34969 | 12/20 | 0.41 |
| ▸ | HTR6 | P50406 | 12/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25316295 | 0.90 | HTR1A (0.47) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25908768 | 0.87 | ALK (0.38) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL30507195 | 0.79 | HTR7 (0.42) | HTR1AHTR2AHTR7HTR6DRD2 | |
| SCHEMBL25318634 | 0.79 | HTR7 (0.42) | HTR1AHTR2AHTR7HTR6DRD2 | |
| SCHEMBL25909333 | 0.79 | IP6K1 (0.38) | HTR1AHTR2AHTR7HTR6DRD2 | |
| SCHEMBL25317717 | 0.77 | HTR1A (0.48) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25317063 | 0.77 | PGR (0.41) | HTR1AHTR2AHTR7HTR6DRD2 | |
| SCHEMBL25910642 | 0.77 | MET (0.32) | — | |
| SCHEMBL25908442 | 0.76 | HTR1A (0.43) | HTR1AHTR2AHTR7HTR6OPRM1 | |
| SCHEMBL25315766 | 0.74 | HRH3 (0.48) | HTR1AHTR2AHTR7HTR6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |