Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588754 | 0.77 | MEN1 (0.31) | DRD2MEN1KMT2A | |
| SCHEMBL6001812 | 0.74 | CTSK (0.32) | KDM1A | |
| SCHEMBL25346836 | 0.70 | KDM1A (0.33) | KDM1A | |
| SCHEMBL5492828 | 0.67 | PREP (0.36) | KDM1AMEN1KMT2A | |
| SCHEMBL2811591 | 0.65 | PLAT (0.37) | KDM1A | |
| SCHEMBL17376304 | 0.64 | PLAT (0.36) | MEN1KMT2A | |
| SCHEMBL17376240 | 0.64 | PLAT (0.39) | MEN1KMT2A | |
| SCHEMBL17113437 | 0.64 | KDM1A (0.39) | KDM1A | |
| SCHEMBL21983574 | 0.63 | JAK3 (0.37) | — | |
| SCHEMBL20955744 | 0.63 | NOTUM (0.57) | KDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563780-A1 | 3, 3 -DISUBSTITUTED- ( 8 - AZA - BICYCLO [3.2.1]OCT- 8 - YL) -[5- (1H - PYRAZOL - 4 -YL) -THIOPHEN-3 -YL]METHANONES AS INHIBITORS OF 11 (BETA) -HSD1 | THE UNIVERSITY OF EDINBURGH (GB) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011135276-A1 | 3, 3 -DISUBSTITUTED- ( 8 - AZA - BICYCLO [3.2.1] OCT- 8 - YL) -[5- (1H - PYRAZOL - 4 -YL) -THIOPHEN-3 -YL] METHANONES AS INHIBITORS OF 11 (BETA) -HSD1 | THE UNIVERSITY OF EDINBURGH (GB) | 2011-11-03 | — | — | WO | disclosed |