Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.38 |
| ▸ | PGR | P06401 | 6/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.34 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25317063 | 0.91 | PGR (0.41) | ALKPGRKCNA5TRPV4IP6K1 | |
| SCHEMBL25908381 | 0.87 | HTR1A (0.41) | DRD2ADRA1DSLC6A4ADRA1AADRA1B | |
| SCHEMBL25317118 | 0.84 | ALK (0.41) | ALKPGRKCNA5IP6K1 | |
| SCHEMBL25317462 | 0.83 | ALK (0.42) | ALKPGRTRPV4DRD2ADRA1D | |
| SCHEMBL30507496 | 0.83 | ALK (0.42) | ALKPGRTRPV4DRD2ADRA1D | |
| SCHEMBL26043799 | 0.83 | PGR (0.42) | ALKPGRKCNA5TRPV4IP6K1 | |
| SCHEMBL25317352 | 0.83 | PGR (0.40) | ALKPGRKCNA5TRPV4IP6K1 | |
| SCHEMBL25317489 | 0.83 | PGR (0.40) | ALKPGRKCNA5TRPV4IP6K1 | |
| SCHEMBL25317873 | 0.83 | PGR (0.40) | ALKPGRKCNA5TRPV4IP6K1 | |
| SCHEMBL25316629 | 0.83 | PGR (0.40) | ALKPGRKCNA5TRPV4IP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |