Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 1.00 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2587913 | 0.92 | NPSR1 (1.00) | NPSR1ASAH1SMN1; SMN2MEN1RAB9A | |
| SCHEMBL2593079 | 0.78 | NPSR1 (1.00) | NPSR1ASAH1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL2586617 | 0.72 | NPSR1 (1.00) | NPSR1ASAH1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL2593998 | 0.72 | NPSR1 (0.63) | NPSR1MEN1KMT2AALDH1A1POLB | |
| SCHEMBL2587268 | 0.72 | NPSR1 (0.63) | NPSR1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL2595693 | 0.71 | NPSR1 (1.00) | NPSR1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL2586615 | 0.70 | NPSR1 (0.54) | NPSR1KDM4EALDH1A1 | |
| SCHEMBL2586743 | 0.69 | NPSR1 (0.58) | NPSR1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL28756722 | 0.68 | GAA (0.52) | NPSR1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL2590676 | 0.66 | NPSR1 (1.00) | NPSR1ASAH1SMN1; SMN2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137220-A1 | SMALL MOLECULE NEUROPEPTIDE S ANTAGONISTS FOR THE TREATMENT OF ADDICTIVE DISORDERS, MOOD, ANXIETY AND SLEEP DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-11-03 | — | — | WO | disclosed |
| WO-2011137220-A1 | SMALL MOLECULE NEUROPEPTIDE S ANTAGONISTS FOR THE TREATMENT OF ADDICTIVE DISORDERS, MOOD, ANXIETY AND SLEEP DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-11-03 | — | — | WO | disclosed |