Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 6/20 | 0.35 |
| ▸ | JAK2 | O60674 | 5/20 | 0.35 |
| ▸ | JAK1 | P23458 | 5/20 | 0.35 |
| ▸ | TYK2 | P29597 | 5/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25909900 | 0.92 | CSF1R (0.54) | CSF1RPDGFRBFLT3LCKKIT | |
| SCHEMBL25910709 | 0.91 | CSF1R (0.42) | CSF1RPDGFRBFLT3LCKKIT | |
| SCHEMBL25910796 | 0.81 | CSF1R (0.52) | CSF1RPDGFRBFLT3LCKKIT | |
| SCHEMBL25909920 | 0.80 | CSF1R (0.45) | CSF1RPDGFRBFLT3LCKKIT | |
| SCHEMBL25910793 | 0.79 | JAK2 (0.36) | CSF1RPDGFRBFLT3LCKKIT | |
| SCHEMBL25911417 | 0.79 | IGF1R (0.43) | IGF1RBRAFJAK2JAK1TYK2 | |
| SCHEMBL25909925 | 0.79 | CSF1R (0.44) | CSF1RPDGFRBFLT3LCKKIT | |
| SCHEMBL25910794 | 0.77 | CSF1R (0.61) | CSF1RPDGFRBFLT3LCKKIT | |
| SCHEMBL25914570 | 0.75 | CSF1R (0.42) | CSF1RPDGFRBFLT3LCKKIT | |
| SCHEMBL25914717 | 0.75 | CSF1R (0.42) | CSF1RPDGFRBFLT3LCKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125812-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |