Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | JAK1 | P23458 | 6/20 | 0.39 |
| ▸ | TYK2 | P29597 | 6/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25910810 | 0.79 | CSF1R (0.44) | IGF1RBRAFJAK2JAK1TYK2 | |
| SCHEMBL25909900 | 0.78 | CSF1R (0.54) | IGF1RBRAFJAK2JAK1TYK2 | |
| SCHEMBL25910709 | 0.77 | CSF1R (0.42) | IGF1RFGFR2FGFR3BRAFJAK2 | |
| SCHEMBL16423613 | 0.76 | CDK19 (0.56) | CDK19ALKJAK2JAK1TYK2 | |
| SCHEMBL16793977 | 0.74 | TYK2 (0.56) | CDK19ALKJAK2JAK1TYK2 | |
| SCHEMBL25911297 | 0.74 | KDR (0.49) | FGFR3KDR | |
| SCHEMBL20532965 | 0.68 | CDK19 (0.47) | CDK19ALKJAK2JAK1TYK2 | |
| SCHEMBL25912399 | 0.68 | KDR (0.44) | FGFR3KDR | |
| SCHEMBL20461251 | 0.68 | JAK2 (0.52) | CDK19ALKJAK2JAK1TYK2 | |
| SCHEMBL16809305 | 0.67 | HCK (0.58) | CDK19ALKJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125812-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |