SCHEMBL25911580

SCHEMBL25911580

CC(C)CC(=O)OC[C@H]1O[C@@](C)(c2ccc3c(N)ncnn23)[C@H](O)[C@@H]1O

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PRKD3 O94806 1/20 0.35
▸ PRKCG P05129 1/20 0.35
▸ PRKCB P05771 1/20 0.35
▸ PRKCA P17252 1/20 0.35
▸ PRKCH P24723 1/20 0.35
▸ PRKCI P41743 1/20 0.35
▸ PRKCE Q02156 1/20 0.35
▸ PRKCQ Q04759 1/20 0.35
▸ PRKCZ Q05513 1/20 0.35
▸ PRKCD Q05655 1/20 0.35
▸ PRKD1 Q15139 1/20 0.35
▸ RIPK1 Q13546 3/20 0.33
▸ POLRMT O00411 1/20 0.33
▸ TMPRSS2 O15393 1/20 0.33
▸ CA12 O43570 4/20 0.31
▸ CA1 P00915 4/20 0.31
▸ CA2 P00918 4/20 0.31
▸ CA9 Q16790 4/20 0.31
▸ CA14 Q9ULX7 4/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24917123 0.90 CA12 (0.36) PRKD3PRKCGPRKCBPRKCAPRKCH
SCHEMBL24917062 0.90 POLRMT (0.34) RIPK1POLRMTTMPRSS2
SCHEMBL24312556 0.90 RIPK1 (0.34) RIPK1POLRMTTMPRSS2
SCHEMBL24916799 0.89 CA12 (0.32) PRKD3PRKCGPRKCBPRKCAPRKCH
SCHEMBL24917156 0.89 CA12 (0.32) PRKD3PRKCGPRKCBPRKCAPRKCH
SCHEMBL26944556 0.88 POLRMT (0.33) RIPK1POLRMTTMPRSS2CA12CA1
SCHEMBL24917588 0.88 CA12 (0.33) PRKD3PRKCGPRKCBPRKCAPRKCH
SCHEMBL24312549 0.88 POLRMT (0.35) RIPK1POLRMTTMPRSS2
SCHEMBL24313023 0.87 POLRMT (0.33) RIPK1POLRMTTMPRSS2
SCHEMBL24312614 0.87 RIPK1 (0.33) RIPK1POLRMTTMPRSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054618-A1 METHODS FOR TREATMENT OF VIRAL INFECTIONS GILEAD SCIENCES, INC. (US) 2024-03-14 — — WO disclosed
WO-2023239665-A1 METHODS FOR TREATMENT OF VIRAL INFECTIONS INCLUDING SARS-COV-2 GILEAD SCIENCES, INC. (US) 2023-12-14 — — WO disclosed
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS VenatoRx Pharmaceuticals, Inc. 2023-07-27 — — US disclosed
US-11638715-B2 Orally-bioavailable nucleoside analogs VenatoRx Pharmaceuticals, Inc. (US) 2023-05-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11638715-B2 Orally-bioavailable nucleoside analogs SLC29A2, SLC29A1, PNP PRKD3 3951/4885PRKCG 3673/4885PRKCB 3851/4885
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS SLC29A2, SLC29A1, PNP PRKD3 3951/4885PRKCG 3673/4885PRKCB 3851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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