Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876346 | 0.87 | RXRA (0.45) | RXRARXRBRXRGGABRG2GABRB3 | |
| SCHEMBL135394 | 0.87 | ALDH1A1 (0.48) | RXRARXRBRXRGSMN1; SMN2NPC1 | |
| SCHEMBL29427056 | 0.87 | ALDH1A1 (0.48) | RXRARXRBRXRGSMN1; SMN2NPC1 | |
| SCHEMBL5352034 | 0.87 | RXRA (0.62) | RXRARXRBRXRGPTPN5SMN1; SMN2 | |
| SCHEMBL25906400 | 0.86 | RXRA (0.59) | RXRARXRBRXRGPTPN5SMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL3178489 | 0.85 | ALDH1A1 (0.46) | RXRARXRBRXRGSMN1; SMN2NPC1 | |
| SCHEMBL1223707 | 0.85 | ALDH1A1 (0.46) | RXRARXRBRXRGSMN1; SMN2NPC1 | |
| Ammonia Solution, Strong SCHEMBL27726646 | 0.85 | ALDH1A1 (0.46) | RXRARXRBRXRGSMN1; SMN2NPC1 | |
| SCHEMBL598181 | 0.84 | RXRA (0.66) | RXRARXRBRXRGPTPN5SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3176977 | 0.83 | IDO1 (0.48) | RXRARXRBRXRGSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | AAAS, PROC, AADAC | RXRA 2013/4885RXRB 1550/4885RXRG 1124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.