Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21910240 | 0.88 | CACNA2D1 (0.43) | OPRD1HRH3OPRM1CACNA2D1CACNA1B | |
| SCHEMBL21910634 | 0.86 | FPR2 (0.42) | OPRD1HRH3OPRM1CACNA2D1CACNA1B | |
| SCHEMBL21831404 | 0.86 | OPRD1 (0.43) | OPRD1HRH3OPRM1MGLL | |
| SCHEMBL21910161 | 0.81 | DPP8 (0.41) | HRH3MGLLFAAHDPP8DPP7 | |
| SCHEMBL7437112 | 0.80 | HRH3 (0.58) | OPRD1HRH3OPRM1CACNA2D1CACNA1B | |
| SCHEMBL7332382 | 0.79 | HRH3 (0.33) | HRH3DPP8DPP7DPP4 | |
| SCHEMBL14033487 | 0.76 | HRH3 (0.44) | OPRD1HRH3OPRM1MGLLFAAH | |
| Acetic Acid SCHEMBL27992925 | 0.76 | OPRD1 (0.65) | OPRD1OPRM1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL21831282 | 0.75 | HRH3 (0.43) | OPRD1HRH3OPRM1CACNA2D1CACNA1B | |
| SCHEMBL27048103 | 0.75 | HRH3 (0.43) | OPRD1HRH3OPRM1CACNA2D1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |