Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033816 | 0.85 | CYP2D6 (0.55) | HRH3CYP2D6CYP19A1OPRM1OPRD1 | |
| SCHEMBL14034022 | 0.85 | CYP2D6 (0.55) | HRH3CYP2D6CYP19A1OPRM1OPRD1 | |
| SCHEMBL13307944 | 0.85 | MEN1 (0.53) | CYP2D6OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7437112 | 0.83 | HRH3 (0.58) | HRH3ACHECYP2D6CYP19A1OPRM1 | |
| SCHEMBL13304693 | 0.81 | KCNH2 (0.52) | HRH3CYP2D6CYP19A1OPRM1OPRD1 | |
| SCHEMBL14033489 | 0.79 | OPRD1 (0.61) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL26673752 | 0.78 | HRH3 (0.46) | HRH3ACHECYP2D6CYP19A1OPRM1 | |
| SCHEMBL14034016 | 0.78 | MEN1 (0.49) | ACHECYP2D6OPRM1OPRD1MEN1 | |
| SCHEMBL21910596 | 0.77 | HRH3 (0.42) | HRH3ACHECYP2D6CYP19A1OPRM1 | |
| SCHEMBL25919486 | 0.76 | OPRD1 (0.42) | HRH3ACHEOPRM1OPRD1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |