Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14922305 | 0.71 | THRA (0.45) | THRATHRBPDK2CHRNB2CHRNA4 | |
| SCHEMBL25919978 | 0.71 | DRD2 (0.40) | — | |
| SCHEMBL14922255 | 0.69 | THRA (0.38) | THRATHRBPDK2CYP2C19L3MBTL1 | |
| SCHEMBL25317341 | 0.68 | THRA (0.37) | THRATHRBCRHR1GPR84PTGES | |
| SCHEMBL12017814 | 0.68 | NOTUM (0.44) | NOTUMCRHR1ALDH1A1 | |
| SCHEMBL9233640 | 0.68 | NOTUM (0.44) | NOTUMCRHR1 | |
| SCHEMBL19649433 | 0.67 | PDK2 (0.46) | THRATHRBGPR84PDK2PTGES | |
| SCHEMBL6718732 | 0.67 | THRA (0.48) | THRATHRBPDK2CHRNB2CHRNA4 | |
| SCHEMBL6846758 | 0.66 | GAA (0.55) | NOTUMCRHR1KDM4EALDH1A1 | |
| SCHEMBL619545 | 0.66 | NOTUM (0.40) | NOTUMCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |