Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 2/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592810 | 0.90 | POLB (0.41) | MEN1KMT2AMAP2K4MAPTSMN1; SMN2 | |
| SCHEMBL11584745 | 0.68 | KMT2A (0.60) | MCL1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL12598081 | 0.68 | POLB (0.73) | MEN1KMT2ASMN1; SMN2POLBMAPK1 | |
| SCHEMBL11171876 | 0.67 | ALDH1A1 (0.54) | MEN1KMT2APOLBCA12CA9 | |
| SCHEMBL12180894 | 0.67 | LMNA (0.44) | MCL1MEN1KMT2ATP53POLB | |
| SCHEMBL11222668 | 0.66 | ALDH1A1 (0.75) | MCL1MEN1KMT2AMAPTTP53 | |
| SCHEMBL11165878 | 0.65 | POLB (0.58) | MEN1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL2591509 | 0.65 | ALDH1A1 (0.44) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11177557 | 0.65 | ALDH1A1 (0.58) | MEN1KMT2ATP53PKMALDH1A1 | |
| SCHEMBL9335131 | 0.65 | KMT2A (0.57) | MEN1KMT2AMAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |