Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TCF4 | P15884 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592029 | 0.90 | MCL1 (0.41) | POLBMAPTKMT2AMEN1CA12 | |
| SCHEMBL2591509 | 0.76 | ALDH1A1 (0.44) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2593108 | 0.74 | NQO2 (0.40) | MAPTGAASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2592617 | 0.74 | MAP2K4 (0.41) | MAPTMAP2K4SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL25311928 | 0.69 | ALDH1A1 (0.61) | POLBMAPTKMT2AMEN1PLAU | |
| SCHEMBL12180880 | 0.69 | LMNA (0.41) | MAPTKMT2AMEN1PLAUGAA | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL4057888 | 0.65 | IL1RN (0.65) | MAPTKMT2AMEN1PLAUGAA | |
| SCHEMBL2741010 | 0.65 | NPC1 (0.66) | MAPTKMT2AMEN1GAACA9 | |
| SCHEMBL5380693 | 0.64 | POLB (0.62) | POLBKMT2AMEN1PLAUGAA | |
| SCHEMBL11165878 | 0.63 | POLB (0.58) | POLBMAPTKMT2AMEN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |