SCHEMBL259247

SCHEMBL259247

CNc1nc(C)cs1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18469863 0.80
SCHEMBL14431689 0.78
SCHEMBL10531759 0.78
SCHEMBL4843604 0.78
SCHEMBL2642510 0.78
Isophthalic Acid SCHEMBL27816983 0.77 RAB9A (0.58)
Hydrochloric Acid SCHEMBL7036884 0.76
SCHEMBL2777930 0.75 FDPS (0.58)
SCHEMBL8302977 0.75
SCHEMBL13665441 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118871112-A Use of 4-thiazol-N- (pyridin-2-yl) pyrimidin-2-amine derivatives in cancer combination therapy 澳升医药公司 2024-10-29 CN claimed
CN-118843465-A Use of 5- (2- ((5- (4- (dimethylamino) piperidin-1-yl) pyridin-2-yl) amino) -5-fluoropyrimidin-4-yl) -N, 4-dimethylthiazol-2-amine in cancer combination therapy 澳升医药公司 2024-10-25 CN claimed
EP-4146201-A1 TREATMENT OF PROLIFERATIVE DISEASES OF THE CNS Aucentra Therapeutics Pty Ltd (AU) 2023-03-15 EP claimed
CN-115666561-A Treatment of proliferative diseases of the CNS 澳升医药公司 2023-01-31 CN claimed
WO-2021222967-A1 TREATMENT OF PROLIFERATIVE DISEASES OF THE CNS AUCENTRA THERAPEUTICS PTY LTD (AU) 2021-11-11 WO claimed
CN-109053623-B Preparation method of 4-methyl-5-thiazole formaldehyde 济南悟通生物科技有限公司 2020-08-04 CN claimed
CN-109053623-A A kind of novel processing step of 4- methyl-5-thiazole formaldehyde 济南悟通生物科技有限公司 2018-12-21 CN claimed
US-5693619-A ENZYME INHIBITORS; ADMINISTERED TO TREAT CONGESTIVE HEART FAILURE AND HYPERTENSION BOEHRINGER INGELHEIM (CANADA), LTD. (CA) 1997-12-02 US claimed
EP-0589446-B1 N-(Hydroxyethyl)butanediamide derivatives as renin inhibitors BOEHRINGER INGELHEIM CA LTD (CA) 1997-09-03 EP claimed
EP-0589445-B1 Renin Inhibiting N-(2-Amino-2-oxoethyl)Butanediamide Derivatives BIO MEGA BOEHRINGER INGELHEIM (CA) 1997-01-15 EP claimed
US-5565476-A RENIN INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND HYPERTENSION BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1996-10-15 US claimed
US-5554634-A HYPOTENSIVE BIO-MEGA BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1996-09-10 US claimed
US-5541163-A HYPOTENSIVE AGENTS BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1996-07-30 US claimed
US-5523315-A N-(hydroxyethyl)butanediamide derivatives BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1996-06-04 US claimed
WO-1994007846-A1 RENIN INHIBITING N-(2-AMINO-2-OXOETHYL)BUTANEDIAMIDE DERIVATIVES BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-04-14 WO claimed
WO-1994007845-A1 N-(HYDROXYETHYL)BUTANEDIAMIDE DERIVATIVES AS RENIN INHIBITORS BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-04-14 WO claimed
EP-0589445-A1 Renin Inhibiting N-(2-Amino-2-oxoethyl)Butanediamide Derivatives BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-03-30 EP claimed
EP-0589446-A1 N-(Hydroxyethyl)butanediamide derivatives as renin inhibitors BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-03-30 EP claimed
US-12404270-B2 Quinazoline derivatives as LPA receptor 2 inhibitors CHIESI FARMACEUTICI S.P.A. (IT) 2025-09-02 US disclosed
EP-0589445-A1 Renin Inhibiting N-(2-Amino-2-oxoethyl)Butanediamide Derivatives BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-03-30 EP disclosed