Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRPS1 | P60891 | 1/20 | 0.44 |
| ▸ | HCAR1 | Q9BXC0 | 5/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14251024 | 0.85 | PRPS1 (0.39) | PRPS1JAK1JAK2AURKAPRKCA | |
| SCHEMBL14251474 | 0.85 | PRPS1 (0.39) | PRPS1JAK1ALDH1A1TP53MAPK1 | |
| SCHEMBL14251472 | 0.85 | PRPS1 (0.39) | PRPS1JAK1ALDH1A1TP53MAPK1 | |
| SCHEMBL14251470 | 0.85 | PRPS1 (0.39) | PRPS1JAK1ALDH1A1TP53MAPK1 | |
| SCHEMBL31698347 | 0.84 | JAK1 (0.51) | PRPS1JAK1JAK2HSD17B10GAA | |
| SCHEMBL31051166 | 0.79 | LMNA (0.40) | PRPS1HCAR1JAK1JAK2AURKA | |
| SCHEMBL25317119 | 0.79 | PRPS1 (0.38) | PRPS1CYP2C9IDO1KCNH2 | |
| SCHEMBL30507104 | 0.79 | PRPS1 (0.38) | PRPS1CYP2C9IDO1KCNH2 | |
| SCHEMBL25924928 | 0.79 | PRPS1 (0.38) | PRPS1CYP2C9IDO1KCNH2 | |
| SCHEMBL14723562 | 0.78 | CYP2C19 (0.43) | PRPS1HSD17B10ALDH1A1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |