Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.67 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588313 | 0.85 | HCRTR1 (0.76) | L3MBTL1HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL27249973 | 0.82 | L3MBTL1 (1.00) | L3MBTL1HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL2592900 | 0.81 | HCRTR1 (1.00) | L3MBTL1HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL2592644 | 0.79 | HCRTR1 (0.70) | L3MBTL1HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL7707718 | 0.78 | HCRTR1 (1.00) | L3MBTL1HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL2594733 | 0.77 | HCRTR1 (0.96) | L3MBTL1HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL7711063 | 0.77 | HCRTR1 (0.96) | L3MBTL1HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL24273464 | 0.77 | LMNA (0.66) | L3MBTL1HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL2588315 | 0.75 | L3MBTL1 (0.65) | L3MBTL1HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL16977268 | 0.74 | CYP19A1 (0.61) | LMNAALDH1A1POLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | claimed |
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |