Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.70 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 9/20 | 0.66 |
| ▸ | THRB | P10828 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592528 | 0.91 | POLB (0.69) | HCRTR1HCRTR2POLBTHRBMAPT | |
| SCHEMBL2594555 | 0.91 | HCRTR1 (0.67) | HCRTR1HCRTR2POLBTHRBMAPT | |
| SCHEMBL2588313 | 0.84 | HCRTR1 (0.76) | HCRTR1HCRTR2POLBTHRBMAPT | |
| SCHEMBL7707718 | 0.82 | HCRTR1 (1.00) | HCRTR1HCRTR2POLBTHRBMAPT | |
| SCHEMBL2592900 | 0.81 | HCRTR1 (1.00) | HCRTR1HCRTR2POLBTHRBMAPT | |
| SCHEMBL7711063 | 0.81 | HCRTR1 (0.96) | HCRTR1HCRTR2POLBTHRBMAPT | |
| SCHEMBL2594733 | 0.81 | HCRTR1 (0.96) | HCRTR1HCRTR2POLBTHRBMAPT | |
| SCHEMBL2592510 | 0.79 | L3MBTL1 (0.70) | HCRTR1HCRTR2POLBTHRBMAPT | |
| SCHEMBL2592641 | 0.78 | L3MBTL1 (0.62) | HCRTR1HCRTR2POLBTHRBMAPT | |
| SCHEMBL2592990 | 0.78 | POLB (0.74) | HCRTR1HCRTR2POLBTHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |