SCHEMBL25929191

SCHEMBL25929191

O=C(Nc1oc2ccccc2c1Br)c1ccc(-n2c3ccccc3c3ccccc32)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 4/20 0.42
HDAC1 Q13547 1/20 0.40
HDAC10 Q969S8 1/20 0.40
ALDH1A1 P00352 5/20 0.39
CA12 O43570 2/20 0.39
CA1 P00915 2/20 0.39
CA2 P00918 2/20 0.39
CA9 Q16790 2/20 0.39
TP53 P04637 5/20 0.39
MAPT P10636 4/20 0.39
HSD17B10 Q99714 2/20 0.39
TSHR P16473 1/20 0.39
AHR P35869 1/20 0.39
MAPK10 P53779 1/20 0.39
PTPN1 P18031 1/20 0.39
HPGD P15428 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29622957 0.81 ALDH1A1 (0.53) ALDH1A1CA12CA1CA2CA9
SCHEMBL25331916 0.81 ALDH1A1 (0.53) ALDH1A1CA12CA1CA2CA9
SCHEMBL25927553 0.80 HDAC1 (0.44) HDAC6HDAC1ALDH1A1SMN1; SMN2RAB9A
SCHEMBL25928104 0.75 ALDH1A1 (0.37) HDAC6ALDH1A1CA12CA1CA2
SCHEMBL25929182 0.73 HDAC6 (0.42) HDAC6HDAC1HDAC10ALDH1A1MAPT
SCHEMBL27981508 0.71 KDM4E (0.58) HDAC6HDAC1HDAC10ALDH1A1MAPT
SCHEMBL17850954 0.69 L3MBTL1 (0.59) HDAC6ALDH1A1TP53MAPTHSD17B10
SCHEMBL12937260 0.69 L3MBTL1 (0.59) HDAC6ALDH1A1TP53MAPTHSD17B10
SCHEMBL30368253 0.69 L3MBTL1 (0.59) HDAC6ALDH1A1TP53MAPTHSD17B10
SCHEMBL30137275 0.68 L3MBTL1 (0.50) HDAC6ALDH1A1MAPTAHRPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023138254-A1 HETEROCYCLIC COMPOUND, AND ORGANIC ELECTROLUMINESCENT MATERIAL AND ELEMENT 上海八亿时空先进材料有限公司 2023-07-27 WO disclosed