SCHEMBL25928104

SCHEMBL25928104

O=C(Nc1oc2ccccc2c1Br)c1ccc(-c2nc3c4ccccc4c4ccccc4c3n2-c2ccccc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.37
EGFR P00533 1/20 0.36
HPGD P15428 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CA9 Q16790 3/20 0.36
CA12 O43570 2/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
TP53 P04637 4/20 0.35
MAPT P10636 2/20 0.35
POLB P06746 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
KDR P35968 4/20 0.35
LMNA P02545 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
ADORA3 P0DMS8 2/20 0.34
TSHR P16473 1/20 0.34
AHR P35869 1/20 0.34
MAPK10 P53779 1/20 0.34
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25927553 0.84 HDAC1 (0.44) ALDH1A1EGFRLMNAHDAC6ADORA3
SCHEMBL25929191 0.75 HDAC6 (0.42) ALDH1A1HPGDCA9CA12CA1
SCHEMBL28576110 0.74 GAA (0.44) ALDH1A1NPSR1MAPTRXFP1LMNA
SCHEMBL29697348 0.73 DHFR (0.50) ALDH1A1EGFRMAPTRXFP1LMNA
SCHEMBL2585957 0.73 DHFR (0.50) ALDH1A1EGFRMAPTRXFP1LMNA
SCHEMBL2585614 0.73 MEN1 (0.46) ALDH1A1NPSR1MAPTRXFP1LMNA
SCHEMBL30507756 0.73 MEN1 (0.46) ALDH1A1NPSR1MAPTRXFP1LMNA
SCHEMBL2631757 0.71 MEN1 (0.48) ALDH1A1HPGDMAPTPOLBLMNA
SCHEMBL25331916 0.71 ALDH1A1 (0.53) ALDH1A1HPGDNPSR1CA9CA12
SCHEMBL29622957 0.71 ALDH1A1 (0.53) ALDH1A1HPGDNPSR1CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023138254-A1 HETEROCYCLIC COMPOUND, AND ORGANIC ELECTROLUMINESCENT MATERIAL AND ELEMENT 上海八亿时空先进材料有限公司 2023-07-27 WO disclosed