Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2668952 | 0.77 | PDE10A (0.47) | PDE10ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL21389568 | 0.75 | PDE10A (0.45) | PDE10ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL7195074 | 0.75 | PDE10A (0.45) | PDE10ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL9933090 | 0.75 | PDE10A (0.45) | PDE10ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL858832 | 0.75 | MAP4K4 (0.46) | PDE10ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL13934565 | 0.71 | RAB9A (0.42) | PDE10ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL9936177 | 0.71 | RAB9A (0.42) | PDE10ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL9933875 | 0.71 | RAB9A (0.45) | PDE10ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL12091358 | 0.71 | NPC1 (0.42) | PDE10ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL13954223 | 0.71 | NPC1 (0.45) | PDE10ANPC1RAB9AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155004-A | Chitosan or chitin derivative and method for processing silver halide photographic material by using the same | FUJI PHOTO FILM CO., LTD. (JP) | 1992-10-13 | — | — | US | claimed |
| EP-0142811-A2 | Method of preparing 1,2,4-triazolo [1,5-a] - pyrimidine-2-sulfonyl chlorides | THE DOW CHEMICAL COMPANY (US) | 1985-05-29 | — | — | EP | claimed |
| JP-6067331-A | — | — | None | — | — | JP | disclosed |
| US-20220144840-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF AMYLOID-RELATED DISEASES | D. E. SHAW RESEARCH, LLC | 2022-05-12 | — | — | US | disclosed |
| WO-2020167567-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF AMYLOID-RELATED DISEASES | D.E. SHAW RESEARCH, LLC (US) | 2020-08-20 | — | — | WO | disclosed |
| US-9592230-B2 | Substituted imidazoles as PDE10A inhibitors | H. LUNDBECK A/S (DK) | 2017-03-14 | — | — | US | disclosed |
| US-9163027-B2 | Substituted triazolo-pyrimidine compounds for modulating cell proliferation differentiation and survival | STATEGICS, INC. (US) | 2015-10-20 | — | — | US | disclosed |
| US-20150190395-A1 | Novel Phenylimidazole Derivatives as PDE10A Enzyme Inhibitors | H. LUNDBECK A/S (DK) | 2015-07-09 | — | — | US | disclosed |
| US-9018217-B2 | Phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2015-04-28 | — | — | US | disclosed |
| US-20150025081-A1 | NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2015-01-22 | — | — | US | disclosed |
| US-8865711-B2 | Phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2014-10-21 | — | — | US | disclosed |
| WO-2004074270-A2 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2004-09-02 | — | — | WO | disclosed |
| EP-1096855-A1 | HERBICIDES WITH SUBSTITUTED PHENYLSULFONYLUREAS FOR CONTROLLING WEEDS IN RICE | Aventis CropScience GmbH (DE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003597-A1 | HERBICIDES WITH SUBSTITUTED PHENYLSULFONYLUREAS FOR CONTROLLING WEEDS IN RICE | AVENTIS CROPSCIENCE GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |
| JP-H0667331-A | SILVER HALIDE PHOTOGRAPHIC SENSITIVE MATERIAL | MITSUBISHI PAPER MILLS LTD | 1994-03-11 | — | — | JP | disclosed |
| US-5155004-A | Chitosan or chitin derivative and method for processing silver halide photographic material by using the same | FUJI PHOTO FILM CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-5075208-A | Releasing a photographically useful compound upon reduction | FUJI PHOTO FILM CO., LTD. (JP) | 1991-12-24 | — | — | US | disclosed |
| EP-0142811-A3 | Method of preparing 1,2,4-triazolo [1,5-a] - pyrimidine-2-sulfonyl chlorides | THE DOW CHEMICAL COMPANY (US) | 1986-03-12 | — | — | EP | disclosed |
| EP-0142811-A2 | Method of preparing 1,2,4-triazolo [1,5-a] - pyrimidine-2-sulfonyl chlorides | THE DOW CHEMICAL COMPANY (US) | 1985-05-29 | — | — | EP | disclosed |
| EP-0142811-A2 | Method of preparing 1,2,4-triazolo [1,5-a] - pyrimidine-2-sulfonyl chlorides | THE DOW CHEMICAL COMPANY (US) | 1985-05-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150190395-A1 | Novel Phenylimidazole Derivatives as PDE10A Enzyme Inhibitors | PDE10A, PDE5A, PDE3B | PDE10A 1/4885NPC1 1261/4885RAB9A 722/4885 |
| US-20220144840-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF AMYLOID-RELATED DISEASES | APP, PSEN1, BACE1 | PDE10A 961/4885NPC1 78/4885RAB9A 1350/4885 |
| US-20150025081-A1 | NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | PDE10A, PDE5A, PDE3B | PDE10A 1/4885NPC1 1261/4885RAB9A 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.