Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576714 | 0.75 | EPHX2 (0.35) | EPHX2SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL2576717 | 0.75 | EPHX2 (0.35) | EPHX2SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL16635759 | 0.73 | SLC6A2 (0.41) | SLC6A2SLC6A4CPT2CPT1ASMN1; SMN2 | |
| SCHEMBL2593261 | 0.72 | CPT2 (0.48) | SLC6A2SLC6A4CPT2CPT1AEPHX2 | |
| SCHEMBL17008339 | 0.71 | SLC6A2 (0.45) | SLC6A2SLC6A4CPT2CPT1ABDKRB1 | |
| SCHEMBL17020281 | 0.71 | SLC6A2 (0.45) | SLC6A2SLC6A4CPT2CPT1ABDKRB1 | |
| SCHEMBL2595492 | 0.69 | SMN1; SMN2 (0.36) | SMN1; SMN2KDM4E | |
| SCHEMBL2596230 | 0.68 | SLC6A2 (0.44) | SLC6A2SLC6A4CPT2CPT1ABDKRB1 | |
| SCHEMBL16635706 | 0.67 | SLC6A2 (0.36) | SLC6A2SLC6A4CPT2CPT1ACNR2 | |
| SCHEMBL2595283 | 0.67 | SMN1; SMN2 (0.40) | SLC6A2SLC6A4CPT2CPT1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569319-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141396-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-17 | — | — | WO | disclosed |