Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 7/20 | 0.42 |
| ▸ | MMP13 | P45452 | 7/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.42 |
| ▸ | MMP1 | P03956 | 6/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30506901 | 0.89 | HTR1A (0.43) | MMP9MMP13ADAM17MMP1HRH3 | |
| SCHEMBL25316383 | 0.89 | HTR1A (0.43) | MMP9MMP13ADAM17MMP1HRH3 | |
| SCHEMBL25317378 | 0.88 | HRH3 (0.44) | MMP9MMP13ADAM17MMP1HRH3 | |
| SCHEMBL25932656 | 0.84 | HRH3 (0.41) | MMP9MMP13ADAM17MMP1HRH3 | |
| SCHEMBL26024617 | 0.81 | KCNH2 (0.37) | MMP9MMP13ADAM17MMP1HRH3 | |
| SCHEMBL26049505 | 0.79 | HTR1A (0.40) | MMP9MMP13ADAM17MMP1HRH3 | |
| SCHEMBL25932252 | 0.79 | HTR1A (0.37) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL25913846 | 0.79 | DRD3 (0.36) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL25932861 | 0.78 | KDM4E (0.41) | DRD3KCNA5 | |
| SCHEMBL25908655 | 0.78 | GPR119 (0.41) | DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |