Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672600 | 0.92 | PRMT5 (0.64) | PRMT5SIGMAR1HTR2CMAOBGSTP1 | |
| Hydrochloric Acid SCHEMBL29923085 | 0.90 | PRMT5 (0.62) | PRMT5SIGMAR1HTR2CMAOBGSTP1 | |
| SCHEMBL10041855 | 0.80 | MAOB (0.50) | MAOBGSTP1LMNACYP1A2PTGS1 | |
| SCHEMBL9492793 | 0.79 | LMNA (0.56) | MAOBGSTP1LMNACYP1A2PTGS1 | |
| SCHEMBL17072360 | 0.78 | GSTP1 (0.49) | MAOBGSTP1LMNACYP1A2PTGS1 | |
| SCHEMBL1954669 | 0.78 | SIGMAR1 (0.77) | SIGMAR1HTR2CMAPTQDPRHTR6 | |
| Hydrochloric Acid SCHEMBL6795900 | 0.77 | HTR2C (0.78) | SIGMAR1HTR2CMAPTQDPRHTR6 | |
| SCHEMBL29505098 | 0.76 | INPPL1 (0.64) | PRMT5SIGMAR1HTR2CQDPRHTR6 | |
| SCHEMBL4002546 | 0.75 | PRMT5 (0.61) | PRMT5SIGMAR1HTR2CMAOBLMNA | |
| SCHEMBL14704894 | 0.74 | QDPR (0.54) | SIGMAR1HTR2CCYP1A2MAPTQDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118574821-A | Compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-08-30 | — | — | CN | disclosed |
| WO-2023139199-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2023-07-27 | — | — | WO | disclosed |