Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589947 | 0.72 | MEN1 (0.46) | MEN1KMT2AL3MBTL1HCRTR1HCRTR2 | |
| SCHEMBL6218343 | 0.68 | HTT (0.43) | MEN1KMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL2591965 | 0.63 | L3MBTL1 (0.51) | MEN1KMT2AL3MBTL1HCRTR1HCRTR2 | |
| SCHEMBL1911882 | 0.61 | TSHR (0.58) | MEN1KMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL10011470 | 0.61 | CA1 (0.52) | MEN1KMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL257997 | 0.61 | MAPT (0.64) | KMT2AL3MBTL1MAPTALDH1A1CA9 | |
| Benzylsulfonylbenzene SCHEMBL780337 | 0.60 | TSHR (0.68) | KMT2AHTR6MAPTALDH1A1FAAH | |
| SCHEMBL9425155 | 0.60 | TSHR (0.53) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| Benzylsulfonylbenzene SCHEMBL1877584 | 0.59 | TSHR (0.66) | KMT2AHTR6MAPTALDH1A1FAAH | |
| SCHEMBL92893 | 0.58 | CA2 (0.58) | KMT2AFAAHPRSS1PRSS2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | claimed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |