Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591965 | 0.89 | L3MBTL1 (0.51) | MEN1KMT2AL3MBTL1HCRTR2HCRTR1 | |
| SCHEMBL2593735 | 0.72 | MEN1 (0.45) | MEN1KMT2AL3MBTL1HCRTR2HCRTR1 | |
| SCHEMBL4635342 | 0.70 | HTR6 (0.42) | MEN1KMT2AHTR6KDM4EALDH1A1 | |
| SCHEMBL9598092 | 0.70 | RAPGEF4 (0.49) | MEN1KMT2AHTR6POLBKDM4E | |
| SCHEMBL3608903 | 0.67 | MEN1 (0.43) | MEN1KMT2AL3MBTL1CYP2C19MAPT | |
| SCHEMBL7166909 | 0.66 | HRH3 (0.40) | MEN1KMT2AL3MBTL1CYP2C19MAPT | |
| SCHEMBL1911882 | 0.65 | TSHR (0.58) | MEN1KMT2AL3MBTL1CYP2C19MAPT | |
| SCHEMBL3597471 | 0.65 | KDM4E (0.55) | MEN1KMT2AL3MBTL1CYP2C19MAPT | |
| SCHEMBL11312012 | 0.64 | KMT2A (0.51) | MEN1KMT2AL3MBTL1CYP2C19MAPT | |
| SCHEMBL1646402 | 0.64 | ALDH1A1 (0.45) | MEN1KMT2AL3MBTL1CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |