Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.53 |
| ▸ | BACE1 | P56817 | 10/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2108443 | 0.82 | SIRT6 (0.43) | SIRT6BACE1BACE2 | |
| SCHEMBL15476644 | 0.80 | SIRT6 (0.62) | SIRT6BACE1ADORA3TSHRMC4R | |
| SCHEMBL30826969 | 0.80 | SIRT6 (0.62) | SIRT6BACE1ADORA3TSHRMC4R | |
| SCHEMBL19645365 | 0.76 | SIRT6 (0.67) | SIRT6BACE1ADORA3TSHRMC4R | |
| SCHEMBL2107109 | 0.75 | MAPK1 (0.44) | SIRT6BACE1BACE2TMEM97SIGMAR1 | |
| SCHEMBL17496554 | 0.74 | SIRT6 (0.42) | SIRT6BACE1TSHRKMT2ATMEM97 | |
| SCHEMBL19645364 | 0.74 | SIRT6 (0.68) | SIRT6BACE1ADORA3TSHRMC4R | |
| SCHEMBL16466573 | 0.73 | SIRT6 (0.57) | SIRT6BACE1ADORA3TSHRMC4R | |
| SCHEMBL30969327 | 0.71 | SIRT6 (0.58) | SIRT6BACE1ADORA3TSHRMC4R | |
| SCHEMBL14165301 | 0.70 | SIRT6 (0.57) | SIRT6BACE1ADORA3TSHRMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566855-A1 | 2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2013-03-13 | — | — | EP | claimed |
| WO-2011138293-A1 | 2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-10 | — | — | WO | claimed |