Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585288 | 0.94 | CD38 (0.33) | RIPK3RIPK1CD38TGFBR1PIM1 | |
| SCHEMBL2595034 | 0.89 | RIPK3 (0.34) | RIPK3RIPK1PIM1PIM2MCL1 | |
| SCHEMBL2594924 | 0.79 | PIK3CA (0.39) | RIPK3RIPK1PIM1PIM2JAK2 | |
| SCHEMBL2594418 | 0.76 | PIK3CA (0.41) | PIK3CAMTORATMATR | |
| SCHEMBL2595324 | 0.75 | RIPK2 (0.38) | RIPK3RIPK1RIPK2CCNCCDK8 | |
| SCHEMBL14717993 | 0.73 | RIPK2 (0.54) | RIPK3RIPK1TGFBR1RIPK2PIK3CA | |
| SCHEMBL2585625 | 0.72 | RIPK3 (0.35) | RIPK3RIPK1TGFBR1PIM1PIM2 | |
| SCHEMBL2595613 | 0.71 | RIPK2 (0.35) | RIPK3RIPK1MCL1RIPK2 | |
| SCHEMBL2588243 | 0.69 | RIPK3 (0.39) | RIPK3RIPK1TGFBR1PIM1PIM2 | |
| SCHEMBL2595020 | 0.68 | PDE4B (0.50) | RIPK3RIPK1TGFBR1RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140442-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-10 | — | — | WO | disclosed |