Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.47 |
| ▸ | GABRE | P78334 | 1/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588264 | 0.88 | CYP19A1 (0.54) | ALDH1A1GAAGABRPGABRDGABRA1 | |
| SCHEMBL2586269 | 0.85 | LMNA (0.52) | L3MBTL1ALDH1A1GAACYP19A1LMNA | |
| SCHEMBL30897273 | 0.76 | ALDH1A1 (0.54) | ALDH1A1GAALMNAGPR84PKM | |
| SCHEMBL15416652 | 0.76 | ALDH1A1 (0.54) | ALDH1A1GAALMNAGPR84PKM | |
| SCHEMBL7031444 | 0.72 | KCNH2 (0.51) | — | |
| SCHEMBL15415994 | 0.72 | PBRM1 (0.52) | ALDH1A1GAANR4A2GPR84PKM | |
| SCHEMBL29557960 | 0.72 | PBRM1 (0.52) | ALDH1A1GAANR4A2GPR84PKM | |
| SCHEMBL27148809 | 0.71 | SLC22A6 (0.50) | ALDH1A1GAAGPR84 | |
| SCHEMBL28320627 | 0.71 | ALDH1A1 (0.63) | ALDH1A1GAALMNAGPR84PKM | |
| SCHEMBL5871352 | 0.70 | MEN1 (0.74) | L3MBTL1ALDH1A1NR4A2GPR84KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |