Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 3/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropyl Alcohol SCHEMBL8414918 | 0.90 | SMN1; SMN2 (0.41) | TDP1SMN1; SMN2MMESLC22A6TP53 | |
| SCHEMBL10977355 | 0.87 | GABRR1 (0.42) | TDP1SMN1; SMN2SLC22A6TP53MAPT | |
| Glycerin SCHEMBL28045644 | 0.86 | SLC22A6 (0.41) | TDP1SMN1; SMN2MMESLC22A6OR51E2 | |
| Alcohol SCHEMBL5029537 | 0.86 | TDP1 (0.37) | TDP1SMN1; SMN2MMESLC22A6 | |
| Ethane SCHEMBL28213012 | 0.86 | TDP1 (0.40) | TDP1SMN1; SMN2MMESLC22A6MAPT | |
| SCHEMBL10698543 | 0.85 | TDP1 (0.43) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL11360544 | 0.85 | TDP1 (0.43) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL42084 | 0.85 | TDP1 (0.43) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL987086 | 0.85 | TDP1 (0.43) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL10698540 | 0.85 | TDP1 (0.43) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566488-A2 | POVIDONE-IODINE TOPICAL COMPOSITION | Microdermis Corporation (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140310-A2 | POVIDONE-IODINE TOPICAL COMPOSITION | MICRODERMIS CORPORATION (US) | 2011-11-10 | — | — | WO | disclosed |
| EP-0291555-A1 | Fingernail cosmetic composition | SHISEIDO COMPANY LIMITED (JP) | 1988-11-23 | — | — | EP | disclosed |