Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 5/20 | 0.49 |
| ▸ | CCNC | P24863 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 2/20 | 0.48 |
| ▸ | GAK | O14976 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.47 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.46 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.46 |
| ▸ | FADS1 | O60427 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 6/20 | 0.43 |
| ▸ | BRAF | P15056 | 6/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717834 | 0.84 | RIPK2 (0.69) | RIPK2CCNCCDK8GAKKCNH2 | |
| SCHEMBL599871 | 0.79 | RIPK2 (0.64) | RIPK2CCNCCDK8GAKKCNH2 | |
| SCHEMBL12180823 | 0.78 | RIPK2 (0.51) | RIPK2GAKKCNH2LCKTGFBR1 | |
| SCHEMBL2593012 | 0.78 | RIPK2 (0.77) | RIPK2GAKKCNH2LCKTGFBR1 | |
| SCHEMBL2595976 | 0.78 | RIPK2 (0.77) | RIPK2GAKKCNH2LCKTGFBR1 | |
| SCHEMBL17059502 | 0.73 | RIPK2 (0.54) | RIPK2GAKKCNH2LCKTGFBR1 | |
| SCHEMBL18274872 | 0.69 | TRPA1 (0.57) | FADS1ADRA2ATRPA1GRM4 | |
| SCHEMBL7346388 | 0.68 | TRPA1 (0.69) | TGFBR1MAPK14FADS1ADRA2ATRPA1 | |
| SCHEMBL17552302 | 0.67 | RIPK2 (0.70) | RIPK2GAKKCNH2LCKTGFBR1 | |
| SCHEMBL516494 | 0.66 | FADS1 (0.57) | FADS1ADRA2AULK1TRPA1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011140442-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-10 | — | — | WO | disclosed |