Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 3/20 | 0.54 |
| ▸ | MGAM | O43451 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 6/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594706 | 1.00 | CA9 (0.54) | CA9MGAMCA12CA1CA2 | |
| SCHEMBL2594707 | 1.00 | CA9 (0.54) | CA9MGAMCA12CA1CA2 | |
| SCHEMBL12177697 | 0.96 | LMNA (0.55) | CA9MGAMCA12CA1CA2 | |
| SCHEMBL12177167 | 0.92 | TDP1 (0.60) | CA9MGAMCA12CA1CA2 | |
| SCHEMBL12177707 | 0.90 | MGAM (0.53) | CA9MGAMCA12CA1CA2 | |
| SCHEMBL12177149 | 0.90 | AURKA (0.53) | CA9MGAMCA12CA1CA2 | |
| SCHEMBL12177159 | 0.87 | ALDH1A1 (0.67) | CA9MGAMCA12CA1CA2 | |
| SCHEMBL12177425 | 0.86 | LMNA (0.56) | CA9MGAMCA12CA1CA2 | |
| SCHEMBL12177528 | 0.84 | ALDH1A1 (0.48) | CA9MGAMCA12CA1CA2 | |
| SCHEMBL12177714 | 0.83 | CA9 (0.69) | CA9MGAMCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011135303-A2 | UBIQUITINATION MODULATORS | ITI SCOTLAND LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |
| WO-2011135303-A2 | UBIQUITINATION MODULATORS | ITI SCOTLAND LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |