Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | GFER | P55789 | 1/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1886013 | 0.88 | KDM4E (0.78) | ALDH1A1KDM4EGFERL3MBTL1KMT2A | |
| SCHEMBL14065435 | 0.83 | ALDH1A1 (0.78) | ALDH1A1KDM4EGFERL3MBTL1KMT2A | |
| SCHEMBL1574696 | 0.83 | KDM4E (0.70) | ALDH1A1KDM4EGFERL3MBTL1KMT2A | |
| SCHEMBL7147155 | 0.81 | ALDH1A1 (0.68) | ALDH1A1KDM4EGFERL3MBTL1KMT2A | |
| SCHEMBL7076958 | 0.79 | ALDH1A1 (0.65) | ALDH1A1KDM4EGFERL3MBTL1KMT2A | |
| SCHEMBL8644046 | 0.79 | KMT2A (0.73) | ALDH1A1KDM4EGFERL3MBTL1KMT2A | |
| SCHEMBL30908421 | 0.79 | KMT2A (0.73) | ALDH1A1KDM4EGFERL3MBTL1KMT2A | |
| SCHEMBL16047420 | 0.78 | ALDH1A1 (0.64) | ALDH1A1KDM4EGFERL3MBTL1KMT2A | |
| SCHEMBL27581989 | 0.78 | KDM4E (0.64) | ALDH1A1KDM4EGFERL3MBTL1KMT2A | |
| SCHEMBL18571753 | 0.78 | ALDH1A1 (0.66) | ALDH1A1KDM4EGFERL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059186-A1 | N-((ISOQUINOLIN-6-YL)METHYL)-1H-PYRAZOLE-4-CARBOXAMID DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS FOR THE TREATMENT OF HEREDITARY ANGIOEDEMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-03-21 | — | — | WO | disclosed |
| EP-3719010-B1 | AROMATIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN) | 2023-07-26 | — | — | EP | disclosed |