Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | NNMT | P40261 | 2/20 | 0.31 |
| ▸ | ATG7 | O95352 | 2/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | GRK5 | P34947 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.30 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572220 | 1.00 | ALDH1A1 (0.34) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C9 | |
| SCHEMBL20692108 | 0.83 | PRMT5 (0.35) | ALDH1A1CYP2D6CYP2C9CYP2C19BCHE | |
| SCHEMBL25949119 | 0.83 | BCHE (0.32) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C9 | |
| SCHEMBL23892576 | 0.83 | EIF2AK3 (0.34) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C9 | |
| SCHEMBL18572000 | 0.80 | PIP4K2A (0.36) | NNMTSLC22A12NAE1CA2GRK5 | |
| SCHEMBL24067683 | 0.80 | PIP4K2A (0.36) | NNMTSLC22A12NAE1CA2GRK5 | |
| SCHEMBL18571703 | 0.78 | GPR119 (0.34) | UBA6 | |
| SCHEMBL18572012 | 0.77 | RXFP1 (0.49) | PRMT5WDR77 | |
| SCHEMBL22683096 | 0.77 | RXFP1 (0.49) | PRMT5WDR77 | |
| SCHEMBL20692203 | 0.76 | PRMT5 (0.33) | BCHEPRMT5WDR77NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |